α-甲基色胺
α-甲基色胺（α-Methyltryptamine，αMT）是一种色胺类致幻剂、兴奋剂、诱导剂。
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| 化学数据 | |
|---|---|
| 化学式 | C11H14N2 |
| 摩尔质量 | 174.25 g·mol−1 |
| 识别信息 | |
| IUPAC名称 | 1-(1H-吲哚-3-基)丙-2-胺 |
| CAS号 | |
| PubChem CID | |
药理学
αMT是血清素、去甲肾上腺素和多巴胺的再摄取抑制剂和释放剂，[1]它同时还是一种非选择性血清素受体激动剂、[2]可逆性单胺氧化酶抑制剂。[3][4]αMT在大鼠的大脑中对MAO-A抑制的效力几乎与等摩尔剂量的骆驼蓬碱相当。[注 1]
法律地位
中国
αMT在中国于2015年被列入非药用类麻醉药品和精神药品管制品种增补目录。
引用文献
- ↑ Nagai F, Nonaka R, Satoh Hisashi Kamimura K (March 2007). "The effects of non-medically used psychoactive drugs on monoamine neurotransmission in rat brain". European Journal of Pharmacology. 559 (2–3): 132–137. doi:10.1016/j.ejphar.2006.11.075. PMID 17223101.
- ↑ Nonaka R, Nagai F, Ogata A, Satoh K (December 2007). "In vitro screening of psychoactive drugs by [(35)S]GTPgammaS binding in rat brain membranes". Biological & Pharmaceutical Bulletin. 30 (12): 2328–2333. doi:10.1248/bpb.30.2328. PMID 18057721.
- ↑ Arai Y, Toyoshima Y, Kinemuchi H (June 1986). "Studies of monoamine oxidase and semicarbazide-sensitive amine oxidase. II. Inhibition by alpha-methylated substrate-analogue monoamines, alpha-methyltryptamine, alpha-methylbenzylamine and two enantiomers of alpha-methylbenzylamine". Japanese Journal of Pharmacology. 41 (2): 191–197. doi:10.1254/jjp.41.191. PMID 3747266.
- ↑ Greig ME, Walk RA, Gibbons AJ (October 1959). "The effect of three tryptamine derivatives on serotonin metabolism in vitro and in vivo". The Journal of Pharmacology and Experimental Therapeutics. 127: 110–115. PMID 13851725.
- ↑ Gey KF, Pletscher A (August 1962). "Effect of alpha-alkylated tryptamine derivatives on 5-hydroxytryptamine metabolism in vivo". British Journal of Pharmacology and Chemotherapy. 19 (1): 161–167. doi:10.1111/j.1476-5381.1962.tb01437.x. PMC 1482243. PMID 13898151.
注释
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