α-甲基色胺

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（重定向自Α-Methyltryptamine）
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Α-甲基色胺
化学数据
化学式C11H14N2
摩尔质量174.25 g·mol−1
识别信息
IUPAC名称1-(1H-吲哚-3-基)丙-2-胺
CAS号
PubChem CID

α-甲基色胺（α-Methyltryptamine，αMT）是一种色胺类致幻剂、兴奋剂、诱导剂。

药理学

αMT是血清素、去甲肾上腺素和多巴胺的再摄取抑制剂和释放剂，[1]它同时还是一种非选择性血清素受体激动剂、[2]可逆性单胺氧化酶抑制剂。[3][4]αMT在大鼠的大脑中对MAO-A抑制的效力几乎与等摩尔剂量的骆驼蓬碱相当。[注 1]

法律地位

中国

αMT在中国于2015年被列入非药用类麻醉药品和精神药品管制品种增补目录。

引用文献

  1. ↑ Nagai F, Nonaka R, Satoh Hisashi Kamimura K (March 2007). "The effects of non-medically used psychoactive drugs on monoamine neurotransmission in rat brain". European Journal of Pharmacology. 559 (2–3): 132–137. doi:10.1016/j.ejphar.2006.11.075. PMID 17223101.
  2. ↑ Nonaka R, Nagai F, Ogata A, Satoh K (December 2007). "In vitro screening of psychoactive drugs by [(35)S]GTPgammaS binding in rat brain membranes". Biological & Pharmaceutical Bulletin. 30 (12): 2328–2333. doi:10.1248/bpb.30.2328. PMID 18057721.
  3. ↑ Arai Y, Toyoshima Y, Kinemuchi H (June 1986). "Studies of monoamine oxidase and semicarbazide-sensitive amine oxidase. II. Inhibition by alpha-methylated substrate-analogue monoamines, alpha-methyltryptamine, alpha-methylbenzylamine and two enantiomers of alpha-methylbenzylamine". Japanese Journal of Pharmacology. 41 (2): 191–197. doi:10.1254/jjp.41.191. PMID 3747266.
  4. ↑ Greig ME, Walk RA, Gibbons AJ (October 1959). "The effect of three tryptamine derivatives on serotonin metabolism in vitro and in vivo". The Journal of Pharmacology and Experimental Therapeutics. 127: 110–115. PMID 13851725.
  5. ↑ Gey KF, Pletscher A (August 1962). "Effect of alpha-alkylated tryptamine derivatives on 5-hydroxytryptamine metabolism in vivo". British Journal of Pharmacology and Chemotherapy. 19 (1): 161–167. doi:10.1111/j.1476-5381.1962.tb01437.x. PMC 1482243. PMID 13898151.

注释

  1. ↑ 抑制MAO的的效果在7μM/kg（1.5mg/kg的骆驼蓬碱、1.2mg/kg的αMT）时相当。在70μM/kg时，αMT的效果比骆驼蓬碱低得多。[5]

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